124531-23-3Relevant academic research and scientific papers
Asymmetric michael addition of 1-acetylindolin-3-ones to β-nitrostyrenes catalyzed by bifunctional thioureas: A simple access to 2-functionalized indoles
Liu, Yao-Zong,Cheng, Rui-Ling,Xu, Peng-Fei
supporting information; experimental part, p. 2884 - 2887 (2011/06/17)
The first asymmetric Michael addition of 1-acetylindolin-3-ones to β-nitrostyrenes has been developed. 2-Substituted indolin-3-one derivatives were obtained with excellent yields (up to 99%) and good stereoselectivities (up to 28:1 dr and 92% ee), which could be transformed into 2-functionalized indoles easily without racemization. This achievement might further contribute to the chemistry and pharmacology of indole-related compounds.
Synthesis and Reactions of 1-Acetyl-2-benzylidene-3-oxo-2,3-dihydroindoles
Buzas, A.,Merour, J. Y.
, p. 458 - 461 (2007/10/02)
1-Acetyl-3-oxo-2,3-dihydroindoles were reacted with substituted benzaldehydes affording 1-acetyl-2-arylmethylene-3-oxo-2,3-dihydroindoles which were selectively reduced by hydrogen; then a Horner-Emmons reaction gave the precursors of 2-substituted trypta
