124534-45-8Relevant academic research and scientific papers
A Metal-Free Approach for Bronsted Acid Promoted C-H Alkylation of Heteroarenes with Alkyl Peroxides
Zeng, Yuehua,Qian, Bo,Li, Yajun,Bao, Hongli
, p. 3250 - 3256 (2018)
A metal-free protocol for Minisci C-H alkylation of heteroarenes using alkyl peroxides as the alkylating reagents and internal oxidants simultaneously under promotion of Bronsted acid has been demonstrated. A series of alkyl substituted heteroarenes were readily prepared by the C-H alkylation in moderate to good yields. A possible pathway involving the addition of alkyl radical to heterocycle followed by rearomatization is described.
Nickel-catalysed para-CH activation of pyridine with switchable regioselective hydroheteroarylation of allylarenes
Lee, Wei-Chih,Chen, Chien-Hung,Liu, Cheng-Yuan,Yu, Ming-Shiuan,Lin, Yung-Huei,Ong, Tiow-Gan
supporting information, p. 17104 - 17107 (2015/12/01)
para-CH activation of pyridine with allylbenzene is described by Ni/Al cooperative catalysis in combination with a bulkier NHC ligand and a Lewis acid, leading to linear hydroheteroarylation products. Interestingly, the branch selectivity can be achieved by using the combination of a less sterically hindered amino-NHC ligand and AlMe3 through tandem reaction of facile alkene isomerization followed by a slow CH bond activation process.
Efficient synthesis of substituted quinolines through intramolecular addition of aryl anion to carbonyl carbon
Kobayashi, Yuichi,Igarashi, Junji,Feng, Chao,Toshifumi,Tojo
, p. 3742 - 3745 (2012/09/25)
Substituted quinolines were synthesized in three steps from the Boc amides of substituted 2-iodoanilines and alkyl vinyl ketones. This method consists of (1) N-Michael addition of the Boc amide of 2-iodoaniline to alkyl vinyl ketone in the presence of Cs2CO3 in MeCN; (2) I-Mg exchange of the adduct with 3.5 equiv of i-PrMgCl·LiCl, and (3) acid-catalyzed reaction (excess AcCl in EtOH) of the resulting alcohol. Six examples are given with good yields.
