1245566-16-8

Basic information

• Product Name: 2-(4-methoxyphenyl)-5-(4-chlorophenyl)-4-(3-methylisoxazol-5-yl)-3-aminopyrrole
• Synonyms: 2-(4-methoxyphenyl)-5-(4-chlorophenyl)-4-(3-methylisoxazol-5-yl)-3-aminopyrrole
• CAS NO: 1245566-16-8
• Molecular Weight: 379.846
• Mol File: 1245566-16-8.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-5-(4-chlorophenyl)-4-(3-methylisoxazol-5-yl)-3-aminopyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-5-(4-chlorophenyl)-4-(3-methylisoxazol-5-yl)-3-aminopyrrole(1245566-16-8)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-5-(4-chlorophenyl)-4-(3-methylisoxazol-5-yl)-3-aminopyrrole(1245566-16-8)

Safety Data

• Hazardous Substances Data: 1245566-16-8(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 1245566-04-4 1-(4-methoxyphenyl)-3-(4-chlorophenyl)-4-(3-methylisoxazol-5-yl)-2-aza-1,3-butadiene 

Relevant articles and documents

Approach to trisubstituted 3-Aminopyrrole derivatives by Yb(OTf) 3-catalyzed [4+1] annulation of 2-Azadiene with Me3SiCN

In the present study, we found a novel approach to the simple and practical synthesis of 3-aminopyrrole derivatives through the four-component coupling reaction of a functionalized silane, a nitrile, an aldehyde, and trimethylsilyl cyanide by Yb(OTf)3-catalyzed annulation of a 2-azabutadiene with trimethylsilyl cyanide. In this paper, we also disclose a single-step transformation of the 3-aminopyrrole framework into the pyrrolo[3,4-b]pyridin-4- one skeleton.