1245567-92-3Relevant academic research and scientific papers
Practical multi-component synthesis of di-or tri-aryl (heteraryl) substituted 2-(pyridin-2-yl)imidazoles from simple building blocks
Wu, Xiao-Jin,Jiang, Ran,Xu, Xiao-Ping,Su, Xiao-Ming,Lu, Wei-Hong,Ji, Shun-Jun
, p. 829 - 835 (2010)
A convenient and highly efficient multicomponent protocol has been developed for the synthesis of various poly-substituted 2-(pyridin-2-yl) imidazoles from 2-cyanopyridine, corresponding aromatic aldehydes, and NH 4OAc/primary amine. Notably, tri-substituted 2-(pyridin-2-yl) imidazoles were highly yielded when aromatic primary amines were used as substrates, but both di-and tri-substituted 2-(pyridin-2-yl)imidazoles were obtained in one pot when some aliphatic primary amines were used as substrates.
