124558-74-3Relevant academic research and scientific papers
Readily Accessible 1,2-Amino Ether Ligands for Enantioselective Intramolecular Carbolithiation
Guyon, Hélène,Boussonnière, Anne,Castanet, Anne-Sophie
, p. 4949 - 4957 (2017)
A new class of chiral 1,2-amino ether ligands, readily accessible from naturally occurring α-amino- or α-hydroxy acids, was found to provide high levels of both conversion and stereocontrol (up to 95:5 er) in intramolecular carbolithiation reactions, outperforming the benchmark ligand (?)-sparteine. The ligand could be used in a substoichiometric amount (0.25 equiv) without significant loss of enantioselectivity.
AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS
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Page/Page column 107; 108, (2016/07/05)
The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).
CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS
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Page/Page column 55, (2009/12/28)
Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
Enantioselective epoxidation of unfunctionalized simple olefins by non-racemic molybdenum(VI)(oxo-diperoxo) complexes
Schurig, V.,Hintzer, K.,Leyrer, U.,Mark, C.,Pitchen, P.,Kagan, H. B.
, p. 81 - 96 (2007/10/02)
Molybdenum(VI)(oxo-diperoxo) complexes bearing bidentate ligands with hydroxy and carbonyl functions show asymmetric induction in the stoichiometric epoxidation of simple prochiral olefins.The influence of the ligand and alkene structure on the enantiomeric excess of the oxiranes has been investigated.The addition of chiral diols to the molybdenum(VI)(oxo-diperoxo) reagents gives high enantiomeric excesses probably because of an efficient kinetic resolution of the oxiranes formed.
