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Usage

Uses

Used in Pharmaceutical Synthesis:
3-hydroxy-1-(4-methoxybenzyl)piperidin-2-one is used as a key intermediate in the synthesis of pharmaceutical drugs, leveraging its unique structural features to contribute to the development of new medications.
Used in Drug Discovery:
As a building block in drug discovery, 3-hydroxy-1-(4-methoxybenzyl)piperidin-2-one is employed to explore its potential in creating novel compounds with therapeutic applications, capitalizing on its chemical properties to enhance drug design and innovation.
Used in Research and Development:
3-hydroxy-1-(4-methoxybenzyl)piperidin-2-one is utilized in research settings to investigate its biological activity and potential uses, with the aim of uncovering new avenues for its application in medicine and other fields.
Used in Safety and Environmental Management:
3-hydroxy-1-(4-methoxybenzyl)piperidin-2-one is handled with caution in industrial and research applications, employing safety guidelines to manage potential health and environmental hazards, ensuring responsible use and disposal of the compound.

Upstream product

• 46441-11-6 1-(4-methoxy-benzyl)-piperidine 
• 110-89-4 piperidine 
• 1250444-10-0 1-(4-methoxybenzyl)piperidine-2,3-dione 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1426691-92-0 (S)-((R)-2-oxopiperidin-3-yl) 2-phenylpropanoate 
• 1426691-91-9 (R)-((R)-2-oxopiperidin-3-yl) 2-phenylpropanoate 
• 1250444-10-0 1-(4-methoxybenzyl)piperidine-2,3-dione 

Relevant academic research and scientific papers

Facile Conversion of α-Acyloxy Amides into 3-Hydroxy-lactams

The new synthetic route to α-acyloxy amides based on Passerini multicomponent reaction followed by transformation into the corresponding five-, six-, and seven-membered 3-hydroxy-lactams has been proposed. The influence of the reaction conditions, which includes substrate structure on the reaction course that led to desired lactams, was studied. The use of various oxo components in the Passerini multicomponent reaction (P-MCR) has been evaluated. The first example of a semicyclic O,O-acetal employed as an aldehyde equivalent in the P-MCR has been reported. Finally, the established protocol was successfully applied for the enantioselective synthesis of 3-hydroxy-lactams, which play a crucial role in the synthesis of the number of bioactive compounds.

Concise and Environmentally Friendly Asymmetric Total Synthesis of the Putative Structure of a Biologically Active 3-Hydroxy-2-piperidone Alkaloid

An asymmetric total synthesis of stereoisomers of a putative structure of 3-hydroxy-2-piperidone alkaloid derivative is described. This route is not only concise and efficient but also is achieved under an environmentally friendly approach. To this end, a direct and double C-H oxidation reaction of simple benzylated piperidine and Baker's yeast reduction of a carbonyl group allowed the rapid access to the optically enriched (S)-1-benzyl-3-hydroxy-2-piperidone in only three steps. The NMR data agreed with those obtained in the first total synthesis (and in discrepancy with the natural product), however, optical rotation did not match with both neither the natural and synthetic material.