46441-11-6

Basic information

• Product Name: Piperidine, 1-[(4-methoxyphenyl)methyl]-
• CAS NO: 46441-11-6
• Molecular Formula: C13H19NO
• Molecular Weight: 205.3
• Mol File: 46441-11-6.mol
• Article Data: 45

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-[(4-methoxyphenyl)methyl]-(46441-11-6)
• EPA Substance Registry System: Piperidine, 1-[(4-methoxyphenyl)methyl]-(46441-11-6)

Safety Data

• Hazardous Substances Data: 46441-11-6(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 824-94-2 p-methoxybenzyl chloride 
• 57700-94-4 N-(p-methoxybenzoyl)piperidine 
• 2591-86-8 N-Formylpiperidine 
• 2746-25-0 p-Methoxybenzyl bromide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-09-4 4-methoxybenzoic acid 
• 7377-26-6 4-Methoxycarbonylbenzoyl chloride 
• 4043-87-2 pipecolic Acid 
• 660-88-8 5-aminopentanoic acid 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 874-90-8 4-methoxybenzonitrile 
• 626-67-5 N-methylcyclohexylamine 

Downstream Products

• 6091-44-7 piperidine hydrochloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 128773-73-9 N-(4-Methoxybenzyl)-δ-valerolactam 
• 1426691-92-0 (S)-((R)-2-oxopiperidin-3-yl) 2-phenylpropanoate 
• 1426691-91-9 (R)-((R)-2-oxopiperidin-3-yl) 2-phenylpropanoate 
• 1245644-82-9 3-hydroxy-1-(4-methoxybenzyl)-piperidin-2-one 
• 1245644-82-9 (S)-3-hydroxy-1-(4-methoxybenzyl)piperidin-2-one 
• 1250444-10-0 1-(4-methoxybenzyl)piperidine-2,3-dione 
• 128773-74-0 1-(4-methoxybenzyl)-5,6-dihydropyridin-2(1H)-one 
• 60737-65-7 1-(p-methoxybenzyl)-2-pyrrolidinone 

Relevant articles and documents

Chemoselective Reduction of Tertiary Amides by 1,3-Diphenyl disiloxane (DPDS)

A convenient procedure for the chemoselective reduction of tertiary amides at room temperature in the presence of air and moisture using 1,3-diphenyldisiloxane (DPDS) is developed. The reaction conditions tolerate a significant number of functional groups including esters, nitriles, secondary amides, carbamates, sulfoxides, sulfones, sulfonyl fluorides, halogens, aryl-nitro groups, and arylamines. The conditions reported are the mildest to date and utilize EtOAc, a preferred solvent given its excellent safety profile and lower environmental impact. The ease of setup and broad chemoselectivity make this method attractive for organic synthesis, and the results further demonstrate the utility of DPDS as a selective reducing agent.

Iodine-Mediated Coupling of Cyclic Amines with Sulfonyl Hydrazides: an Efficient Synthesis of Vinyl Sulfone Derivatives

An efficient iodine-mediated coupling of cyclic amines with sulfonyl hydrazides is reported. This transformation opens a new route to the synthesis of vinyl sulfones derivatives, which is a common structural motif in natural products and pharmaceuticals. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.

Intramolecular Csp3-H/C-C bond amination of alkyl azides for the selective synthesis of cyclic imines and tertiary amines

The intramolecular Csp3-H and/or C-C bond amination is very important in modern organic synthesis due to its efficiency in the construction of diversified N-heterocycles. Herein, we report a novel intramolecular cyclization of alkyl azides for the synthesis of cyclic imines and tertiary amines through selective Csp3-H and/or C-C bond cleavage. Two C-N single bonds or a CN double bond are efficiently constructed in these transformations. The carbocation mechanism differs from the reported metal nitrene intermediates and therefore enables metal-free and new transformation.