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Usage

Uses

Used in Pharmaceutical Industry:
(4-CHLORO-PHENYL)-CYCLOPROPYLMETHYL-AMINE HYDROCHLORIDE is used as a pharmaceutical intermediate for the synthesis of various bioactive compounds. Its unique structure, including the chloro and phenyl groups, makes it a valuable building block in the development of pharmaceuticals with potential applications in the treatment of various diseases.
Used in Organic Synthesis:
(4-CHLORO-PHENYL)-CYCLOPROPYLMETHYL-AMINE HYDROCHLORIDE is used as a key component in the synthesis of various organic compounds. Its versatility and stability as a hydrochloride salt make it an ideal candidate for use in chemical processes, facilitating the creation of new compounds with potential applications in various industries.

Upstream product

• 106-39-8 bromochlorobenzene 
• 2516-47-4 cyclopropanemethylamine 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 1245703-51-8 5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbaldehyde 
• 1245734-61-5 5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid 

Relevant academic research and scientific papers

Tandem benzophenone amino pyridines, potent and selective inhibitors of human leukotriene C4 synthase

Cysteinyl leukotrienes (cys-LTs) are lipid mediators of inflammation. The enzyme catalyzing synthesis of cys-LTs, leukotriene C4 synthase (LTC4S), is considered an important drug target. Here we report the synthesis and characterization of thre

Ligand-free CuSO4-catalyzed C-N coupling reaction of aryl halides with alkylamines or N-heterocycles in aqueous solution system

C-N coupling can be achieved successfully under 80°C in aqueous nBu4NOH using CuSO4 as a catalyst. The study of substrate applicability demonstrated that the C-N coupling reaction of aryl iodides and bromides with alkylamines or N-heterocycles could be completed smoothly in this catalytic system.

Cu-catalyzed carbon-heteroatom coupling reactions under mild conditions promoted by resin-bound organic ionic bases

Resin-bound organic ionic bases (RBOIBs) were developed in which tetraalkyl-ammonium or phosphonium cations are covalently attached to solid resins. The application tests showed that the performance of the tetraalkyl-ammonium-type RBOIBs is slightly better than that of the corresponding Cs salts in Cu-catalyzed C-N cross-couplings, while the tetraalkylphosphonium-type RBOIBs are significantly better than all the inorganic bases. With these newly developed RBOIBs, room-temperature Cu-catalyzed C-Ncoupling with various nonactivated aryl iodides and even aryl bromides can be readily accomplished. Moreover, RBOIBs can be easily recycled and reused for a number of times without much drop of activity. The good performances of RBOIBs are proposed to arise from the relatively weak binding forces between the cationic polymer backbone and basic anions, as opposed to the strong metal-anion interactions in the inorganic bases. Further applications of RBOIBs in Ni-catalyzed Suzuki-type couplings at room temperature, Cu-catalyzed C-N couplings at -30 °C, a Pd-catalyzed Heck reaction at 60 °C, and Cu-catalyzed C-S couplings at room temperature demonstrate that RBOIBs are generally applicable bases with improved performance for many other types of organic transformations.