1245705-43-4Relevant articles and documents
Multicomponent tandem synthesis of oxospirobicyclic butenolidobarbiturates
Teimouri, Mohammad Bagher,Abbasi, Tayyebeh,Khavasi, Hamid Reza
experimental part, p. 310 - 314 (2010/10/21)
Novel oxospirobicyclic γ-butenolides containing barbiturate moiety have been synthesised by the Michael-addition of primary amines to dialkyl acetylenedicarboxylates followed by aldol-like reaction with alloxan derivatives, and then ?-lactonisation. Subsequent 1,4-addition of water and elimination of the amine group completes the sequence. This tandem reaction sequence represents a rapid and unprecedented route to the described biologically interesting molecules.