2757-85-9

Basic information

• Product Name: 1,3-dimethylalloxan
• Synonyms: 1,3-dimethylalloxan
• CAS NO: 2757-85-9
• Molecular Formula: C₆H₆N₂O₄
• Molecular Weight: 170.12284
• EINECS: 220-417-3
• Mol File: 2757-85-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 247.7°Cat760mmHg
• Flash Point: 108°C
• Appearance: /
• Density: 1.485g/cm³
• Vapor Pressure: 0.0253mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: 1,3-dimethylalloxan(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dimethylalloxan(2757-85-9)
• EPA Substance Registry System: 1,3-dimethylalloxan(2757-85-9)

Safety Data

• Hazardous Substances Data: 2757-85-9(Hazardous Substances Data)

Usage

General Description

1,3-dimethylalloxan is a chemical compound that is derived from alloxan, a potent diabetogenic compound. It is commonly used in the laboratory to induce diabetes in animal models for research purposes. The chemical is known to cause damage to pancreatic beta cells, which are responsible for producing insulin. 1,3-dimethylalloxan is a reactive compound that forms free radicals, leading to oxidative stress and destruction of the beta cells. As a result, it can be useful in studying the mechanisms of diabetes and potential treatments for the disease. However, its toxic effects limit its use in therapeutic applications.

InChI:InChI=1/C6H6N2O4/c1-7-4(10)3(9)5(11)8(2)6(7)12/h1-2H3

Upstream product

• 2835-45-2 amalic acid 
• 30537-82-7 betaine of 1,3-dimethyl-5-phenyliodoniobarbituric acid 
• 64-17-5 ethanol 
• 58-08-2 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione 
• 769-42-6 1,3-dimethylbarbituric acid 
• 7664-93-9 sulfuric acid 
• 21544-73-0 5,5-dichloro-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione 
• 7732-18-5 water 
• 7697-37-2 nitric acid 
• 58378-09-9 1,3,1',3'-tetramethylhydurilic acid 
• 67-56-1 methanol 
• 30066-93-4 5-amino-1,3-dimethyl-pyrimidine-2,4,6-(1H,3H,5H)-trione 
• 7782-50-5 chlorine 
• 58-55-9 theophylline 

Downstream Products

• 7366-48-5 3,6,8-trimethyl-1-oxa-3,6,8-triaza-spiro[4.4]nonane-2,4,7,9-tetraone 
• 74-89-5 methylamine 
• 2962-90-5 1,3-dimethylalloxazine 
• 14684-48-1 1,3-dimethyllumichrome 
• 99185-73-6 3-oxo-3,4-dihydro-quinoxaline-2-carboxylic acid methylamide 
• 5417-13-0 1,3-dimethylvioluric acid 
• 1084797-80-7 methyl 3-(benzylamino)-2-(5-hydroxy-1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2-propenoate 
• 1084797-95-4 ethyl 3-(phenylamino)-2-(5-hydroxy-1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2-propenoate 
• 1084797-92-1 ethyl 3-(benzylamino)-2-(5-hydroxy-1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2-propenoate 
• 1245705-44-5 benzylammonium 4-(ethoxycarbonyl)-7,9-dimethyl-2,6,8,10-tetraoxo-1-oxa-7,9-diazaspiro[4.5]dec-3-en-3-olate 
• 1245705-46-7 phenylammonium 4-(ethoxycarbonyl)-7,9-dimethyl-2,6,8,10-tetraoxo-1-oxa-7,9-diazaspiro[4.5]dec-3-en-3-olate 
• 1245705-39-8 phenylammonium 4-(methoxycarbonyl)-7,9-dimethyl-2,6,8,10-tetraoxo-1-oxa-7,9-diazaspiro[4.5]dec-3-en-3-olate 
• 1245705-43-4 (4-hydroxyphenyl)ammonium 4-(ethoxycarbonyl)-7,9-dimethyl-2,6,8,10-tetraoxo-1-oxa-7,9-diazaspiro[4.5]dec-3-en-3-olate 
• 1231160-67-0 ethyl 3-(benzylamino)-7,9-dimethyl-2,6,8,10-tetraoxo-1-oxa-7,9-diazaspiro[4.5]dec-3-ene-4-carboxylate 

Relevant articles and documents

Comparison of the Electrochemical and Enzymic Oxidation of 1,3,7-Trimethyluric Acid at Solid Electrodes

The electrochemical oxidation of 1,3,7-trimethyluric acid has been studied in phosphate buffers in the pH range 2.1-10.2 at solid electrodes. In cyclic voltammetry a single, well defined, pH-dependent oxidation peak was obtained at all of the three electrodes used. However, the reduction behavior of the oxidation product was different at pyrolytic graphite, glassy carbon (GCE), and platinum due to adsorption at PGE and GCE. The nature of the electrode reaction was established as EC, in which a charge transfer is followed by competitive chemical reactions. The formation of the same UV-absorbing intermediate and products and identical rate constants for the decay of the UV-absorbing intermediate indicated that the electrochemical oxidation of 1,3,7-trimethyluric acid proceeds by an identical mechanism at PGE, GCE, and Pt. The results of a peroxidase-catalyzed oxidation of 1,3,7-trimethyluric acid were compared with the electrochemical oxidation; it is concluded that both of the oxidations follow a similar pathway.

Murexide reaction of caffeine using nitric acid

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PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS

Photoactive probes and probe systems for detecting biological interactions are described. The photoactive probes include probes that combine both photocleavable and photoreactive moieties. The photoactive probe systems can include a first probe comprising a photocatalytic group and a second probe comprising a group that can act as a substrate for the reaction catalyzed by the photocatalytic group. The probes and probe systems can also include groups that can specifically bind to a binding partner on a biological entity of interest and a detectable group or a precursor thereof. The probes and probe systems can detect spatiotemporal interactions of proteins or cells. In some embodiments, the interactions can be detected in live cells. Also described are methods of detecting the biological interactions.

Catalytic Amine Oxidation under Ambient Aerobic Conditions: Mimicry of Monoamine Oxidase B

The flavoenzyme monoamine oxidase (MAO) regulates mammalian behavioral patterns by modulating neurotransmitters such as adrenaline and serotonin. The mechanistic basis which underpins this enzyme is far from agreed upon. Reported herein is that the combination of a synthetic flavin and alloxan generates a catalyst system which facilitates biomimetic amine oxidation. Mechanistic and electron paramagnetic (EPR) spectroscopic data supports the conclusion that the reaction proceeds through a radical manifold. This data provides the first example of a biorelevant synthetic model for monoamine oxidase B activity.