1245716-52-2Relevant academic research and scientific papers
4-aryl-pyrimidin-2-yl tosylates as efficient reaction partners: Application to the synthesis of pyrimidines functionalised with propargyloxy and 1,2,3-triazolo groups
Quan, Zheng-Jun,Fang, Shao-Wei,Da, Yu-Xia,Zhang, Zhang,Wang, Xi-Cun
, p. 170 - 173 (2015/06/02)
The 4-arylated pyrimidin-2-yl tosylate derivatives, easily prepared from cheap commercial materials, reacted efficiently with propargyl alcohol/NaOBut to give the corresponding 4-arylated 2-propargyloxy-pyrimidine derivatives which, in a onepot
Palladium(II) catalyzed Suzuki/Sonogashira cross-coupling reactions of sulfonates: An efficient approach to C2-functionalized pyrimidines and pyridines
Quan, Zheng-Jun,Jing, Fu-Qiang,Zhang, Zhang,Da, Yu-Xia,Wang, Xi-Cun
, p. 7175 - 7183 (2013/11/06)
Pyrimidin-2-yl sulfonates, as a reaction partner, can be easily prepared from inexpensive commercial materials and are efficiently cross-coupled with arylboronic acids and terminal alkynes by using Pd(OAc)2-catalyzed Suzuki and Sonogashira reactions. A wide array of C2-functionalized pyrimidines have been prepared in good to excellent yields. 2-Arylpyridines and 2-(oct-1-ynyl)pyridine were also synthesized. An efficient means to synthesize expanded pyrimidin-2-yl conjugated systems was developed by using Pd(OAc) 2-catalyzed cross-coupling reaction of pyrimidin/pyridin-2-yl sulfonates with arylboronic acids and terminal alkynes. Compared with 2-chloropyrimidines, pyrimidin-2-yl sulfonates can be easily prepared from inexpensive commercial materials and the reactions are more efficient. Copyright
Synthesis of 2-substituted pyrimidines via cross-coupling reaction of pyrimidin-2-yl sulfonates with nucleophiles in polyethylene glycol 400
Wang, Xi-Cun,Yang, Guo-Jun,Quan, Zheng-Jun,Ji, Peng-Yan,Liang, Jun-Ling,Ren, Rong-Guo
supporting information; experimental part, p. 1657 - 1660 (2010/08/20)
A mild and rapid procedure to the synthesis of 2-substituted pyrimidines was developed via sequential functionalization of easily available Biginelli 3,4-dihydropyrimidine-2(1H)-ones via oxidation, esterification, followed by cross-coupling reaction of pyrimidin-2-yl sulfonates with N, S, and O nucleophiles in PEG-400 as a green reaction medium at room temperature. Georg Thieme Verlag Stuttgart New York.
