1245738-61-7

Basic information

• Product Name: 8-fluoro-4-oxo-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide
• Synonyms: 8-fluoro-4-oxo-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide
• CAS NO: 1245738-61-7
• Molecular Weight: 422.379
• Mol File: 1245738-61-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 8-fluoro-4-oxo-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 8-fluoro-4-oxo-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide(1245738-61-7)
• EPA Substance Registry System: 8-fluoro-4-oxo-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide(1245738-61-7)

Safety Data

• Hazardous Substances Data: 1245738-61-7(Hazardous Substances Data)

Upstream product

• 1024605-91-1 tert-butyl 8-fluoro-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxylate 
• 455-14-1 4-trifluoromethylphenylamine 
• 699-92-3 1-(3-fluoro-2-hydroxyphenyl)-ethanone 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1207163-73-2 8-fluoro-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine] hydrochloride 
• 23779-14-8 phenyl N-[4-(trifluoromethyl)-phenyl]carbamate 

Downstream Products

• 1245738-06-0 (±)-8-fluoro-4-hydroxy-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide 

Relevant articles and documents

Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro- 1′H-spiro[chromene-2,4′-piperidine]-1′-carboxamides as TRPM8 antagonists

A novel series of N-aryl-3,4-dihydro-1′H-spiro[chromene-2,4′- piperidine]-1′-carboxamides was identified as transient receptor potential melastatin 8 (TRPM8) channel blockers through analogue-based rational design, synthesis and screening. Details of the synthesis, effect of aryl groups and their substituents on in-vitro potency were studied. The effects of selected functional groups on the 4-position of the chromene ring were also studied, which showed interesting results. The 4-hydroxy derivatives showed excellent potency and selectivity. Optical resolution and screening of alcohols revealed that (R)-(-)-isomers were in general more potent than the corresponding (S)-(+)-isomers. The isomer (R)-(-)-10e (IC50: 8.9 nM) showed a good pharmacokinetic profile upon oral dosing at 10 mg/kg in Sprague-Dawley (SD) rats. The compound (R)-(-)-10e also showed excellent efficacy in relevant rodent models of neuropathic pain.