1245749-90-9

Basic information

• Product Name: C₁₇H₁₁BrF₃N₃O₂
• CAS NO: 1245749-90-9
• Molecular Weight: 426.192
• Mol File: 1245749-90-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₁BrF₃N₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₁BrF₃N₃O₂(1245749-90-9)
• EPA Substance Registry System: C₁₇H₁₁BrF₃N₃O₂(1245749-90-9)

Safety Data

• Hazardous Substances Data: 1245749-90-9(Hazardous Substances Data)

Upstream product

• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 
• 25947-11-9 1,2-Dihydro-1-oxophthalazin-4-ylacetic acid 
• 57691-07-3 ethyl [(E)-3-oxo-1,3-dihydroisobenzofuran-1-ylidene]acetate 
• 85-44-9 phthalic anhydride 

Relevant articles and documents

Phthalazinone inhibitors of inosine-5′-monophosphate dehydrogenase from Cryptosporidium parvum

Cryptosporidium parvum (Cp) is a potential biowarfare agent and major cause of diarrhea and malnutrition. This protozoan parasite relies on inosine 5′-monophosphate dehydrogenase (IMPDH) for the production of guanine nucleotides. A CpIMPDH-selective N-aryl-3,4-dihydro-3-methyl-4-oxo-1- phthalazineacetamide inhibitor was previously identified in a high throughput screening campaign. Herein we report a structure-activity relationship study for the phthalazinone-based series that resulted in the discovery of benzofuranamide analogs that exhibit low nanomolar inhibition of CpIMPDH. In addition, the antiparasitic activity of select analogs in a Toxoplasma gondii model of C. parvum infection is also presented.