1245749-97-6

Basic information

• Product Name: 4-oxo-N-(3,4-dichlorophenyl)-[1]benzopyrano[4,3-c]pyrazole-1(4H)acetamide
• CAS NO: 1245749-97-6
• Molecular Weight: 388.21
• Mol File: 1245749-97-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-oxo-N-(3,4-dichlorophenyl)-[1]benzopyrano[4,3-c]pyrazole-1(4H)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-oxo-N-(3,4-dichlorophenyl)-[1]benzopyrano[4,3-c]pyrazole-1(4H)acetamide(1245749-97-6)
• EPA Substance Registry System: 4-oxo-N-(3,4-dichlorophenyl)-[1]benzopyrano[4,3-c]pyrazole-1(4H)acetamide(1245749-97-6)

Safety Data

• Hazardous Substances Data: 1245749-97-6(Hazardous Substances Data)

Upstream product

• 22303-31-7 2-bromo-N-(3,4-dichloro-phenyl)-acetamide 
• 95-76-1 m,p-dichloroaniline 
• 50329-91-4 4-chloro-3-formylcoumarin 

Relevant articles and documents

Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole cryptosporidium parvum inosine 5′-monophosphate dehydrogenase (Cp IMPDH) inhibitors

Cryptosporidium inosine 5′-monophosphate dehydrogenase (CpIMPDH) has emerged as a therapeutic target for treating Cryptosporidium parasites because it catalyzes a critical step in guanine nucleotide biosynthesis. A 4-oxo-[1]benzopyrano[4,3-c]pyrazole derivative was identified as a moderately potent (IC50 = 1.5 μM) inhibitor of CpIMPDH. We report a SAR study for this compound series resulting in 8k (IC50 = 20 ± 4 nM). In addition, an X-ray crystal structure of CpIMPDH·IMP·8k is also presented.