22303-31-7

Basic information

• Product Name: 2-bromo-N-(3,4-dichlorophenyl)acetamide
• Synonyms: 2-bromo-N-(3,4-dichlorophenyl)acetamide;acetamide, 2-bromo-N-(3,4-dichlorophenyl)-;2-bromo-N-(3,4-dichlorophenyl)ethanamide
• CAS NO: 22303-31-7
• Molecular Formula: C₈H₆BrCl₂NO
• Molecular Weight: 282.94934
• Mol File: 22303-31-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-bromo-N-(3,4-dichlorophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-(3,4-dichlorophenyl)acetamide(22303-31-7)
• EPA Substance Registry System: 2-bromo-N-(3,4-dichlorophenyl)acetamide(22303-31-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 22303-31-7(Hazardous Substances Data)

Upstream product

• 22118-09-8 2-bromoacetyl chloride 
• 95-76-1 m,p-dichloroaniline 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 1019401-28-5 1-[(3,4-dichloro-phenylcarbamoyl)-methyl]-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 1019400-30-6 C₁₅H₁₅Cl₂N₃O₃ 
• 1245749-97-6 4-oxo-N-(3,4-dichlorophenyl)-[1]benzopyrano[4,3-c]pyrazole-1(4H)acetamide 
• 1010393-06-2 N-(3,4-dichloro-phenyl)-2-isobutylamino-acetamide hydrobromide 

Relevant articles and documents

Design, synthesis and biological evaluation of novel thiazole-based derivatives as human Pin1 inhibitors

Pin1 is a peptidyl prolyl cis-trans isomerase (PPIase) and inhibiting Pin1 is a potential way for discovering anti-tumor agents. With an aim to find potent Pin1 inhibitors with a novel scaffold, a series of thiazole derivatives with an alicyclic heterocycles on the 2-position were designed, synthesized and tested against human Pin1. Compound 9p bearing a 2-oxa-6-azaspiro [3,3] heptane moiety on the thiazole scaffold was identified as the most potent Pin1 inhibitor of this series with an IC50 value of 0.95 μM. The structure-activity relationship (SAR) and molecular modeling study indicated that introducing an alicyclic ring with an H-bond acceptor would be a viable way to improve the binding affinity.

Design and synthesis of 2-((1H-indol-3-yl)thio)-N-phenyl-acetamides as novel dual inhibitors of respiratory syncytial virus and influenza virus A

Respiratory syncytial virus (RSV) and influenza A virus (IAV) are two of the most common viruses that cause substantial morbidity and mortality in infants, young children, elderly persons, and immunocompromised individuals worldwide. Currently, there are

3-position functionalized N (O,S)-heteroindene derivatives and application thereof in resistance of respiratory syncytial virus

The invention discloses 3-position functionalized N (O,S)-heteroindene derivatives and application thereof in resistance of respiratory syncytial virus. The structures of the derivatives are describedin the description, wherein n is 0 or 1; X represents a