124576-41-6Relevant academic research and scientific papers
Furyl, phenylene, and thienyl leukotriene B4 analogues
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, (2008/06/13)
This invention relates to a compound of the formula: STR1 or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, or --CH=CH--; wherein Z is OR1 or --NR4 R5 ; wherein R1 is hydrogen, lower alkyl, or a pharmaceutically acceptable cation; wherein R2 is H, --CH3 or --C2 H5 ; wherein R3 is OH, H or =O; wherein R4 and R5 may independently be hydrogen, or lower alkyl having 1-6 carbon atoms, or R4 and R5 may act together with N to form a cyclic amide of the formula: STR2 wherein n is an integer from 4-5; and m is an integer from 0-4. More particularly, this invention relates to compounds of the above formula which have utility as LTB4 antagonists.
