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2-(4-hydroxyphenyl)propionic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

124578-19-4

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124578-19-4 Usage

Explanation

This is the chemical name of the compound, which is also commonly known as ibuprofen.

Explanation

Ibuprofen belongs to a class of drugs called NSAIDs, which are known for their anti-inflammatory properties and ability to relieve pain.

Explanation

Ibuprofen works by blocking the enzymes responsible for creating prostaglandins, which are chemicals that contribute to inflammation, pain, and fever.

Explanation

Ibuprofen is used to alleviate various symptoms, such as pain, swelling, and fever, that are associated with different conditions.

Explanation

Ibuprofen is often prescribed or taken over the counter to treat these specific conditions, as it effectively addresses their symptoms.

Explanation

Ibuprofen can be purchased without a prescription in various forms, making it easily accessible for consumers.

Explanation

It is crucial to follow the recommended dosage and be aware of potential side effects or interactions with other drugs, as ibuprofen can cause adverse reactions in some individuals.

Classification

Nonsteroidal anti-inflammatory drug (NSAID)

Function

Inhibits the production of prostaglandins

Uses

Relieves pain, reduces inflammation, and lowers fevers

Common treatments

Headaches, menstrual cramps, arthritis, and minor injuries

Availability

Over the counter in tablets, capsules, and suspensions

Precautions

Side effects and interactions with other medications

Check Digit Verification of cas no

The CAS Registry Mumber 124578-19-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,5,7 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 124578-19:
(8*1)+(7*2)+(6*4)+(5*5)+(4*7)+(3*8)+(2*1)+(1*9)=134
134 % 10 = 4
So 124578-19-4 is a valid CAS Registry Number.

124578-19-4Relevant articles and documents

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts

Le Manach, Claire,Dam, Jean,Woodland, John G.,Kaur, Gurminder,Khonde, Lutete P.,Brunschwig, Christel,Njoroge, Mathew,Wicht, Kathryn J.,Horatscheck, André,Paquet, Tanya,Boyle, Grant A.,Gibhard, Liezl,Taylor, Dale,Lawrence, Nina,Yeo, Tomas,Mok, Sachel,Eastman, Richard T.,Dorjsuren, Dorjbal,Talley, Daniel C.,Guo, Hui,Simeonov, Anton,Reader, Janette,Van Der Watt, Mari?tte,Erlank, Erica,Venter, Nelius,Zawada, Jacek W.,Aswat, Ayesha,Nardini, Luisa,Coetzer, Theresa L.,Lauterbach, Sonja B.,Bezuidenhout, Belinda C.,Theron, Anjo,Mancama, Dalu,Koekemoer, Lizette L.,Birkholtz, Lyn-Marie,Wittlin, Sergio,Delves, Michael,Ottilie, Sabine,Winzeler, Elizabeth A.,Smith, Dennis,Fidock, David A.,Street, Leslie J.,Basarab, Gregory S.,Duffy, James,Chibale, Kelly

supporting information, p. 2291 - 2309 (2021/03/01)

A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold provided an attractive starting point for a hit-to-lead medicinal chemistry optimization and biological profiling program. Structure-activity-relationship studies led to the identification of compounds that showed low nanomolar asexual blood-stage activity (50 nM) together with strong gametocyte sterilizing properties that translated to transmission-blocking activity in the standard membrane feeding assay. Mechanistic studies through resistance selection with one of the analogues followed by whole-genome sequencing implicated the P. falciparum cyclic amine resistance locus in the mode of resistance.

Lipase-catalyzed hydrolysis of 2-(4-hydroxyphenyl)propionic acid ethyl ester to (R)-(?)-2-(4-hydroxyphenyl)propanoic acid

Yuan, Xin,Zhang, Panliang,Liu, Guangyong,Xu, Weifeng,Tang, Kewen

, p. 2461 - 2468 (2019/07/16)

Stereoselective hydrolysis of (±)-2-(4-hydroxyphenyl)propionic acid ethyl ester (2-HPPAEE) by lipase catalyzed in aqueous system was investigated. Lipase AK with higher catalytic activity and enantioselectivity was selected as catalyst. Simultaneously, factors affecting the conversion of substrate (c) and the enantiomeric excess of product (eep) were optimized. The optimal conditions were established, involving 45?°C of temperature, 5.5 of pH, 10?mg of lipase AK dosage, 0.04?mmol of substrate dosage and 40?h of reaction time. Under the optimum conditions, c and eep could reach up to 49% and 98%, respectively.

PROPIONIC ACID DERIVATIVE

-

, (2008/06/13)

A propionic acid derivative represented by general formula (I) or a pharmaceutically acceptable acid-addition salt thereof, wherein A represents OH, C1-C8 lower alkoxy, -NR1R2, or C1-C8 lower alkoxy which may be substituted by halogen, optionally susbtitu

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