1245786-16-6Relevant articles and documents
Design, synthesis, and in vitro pharmacology of new radiolabeled γ-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity γ-hydroxybutyric acid binding sites
Sabbatini, Paola,Wellendorph, Petrine,H?g, Signe,Pedersen, Martin H. F.,Br?uner-Osborne, Hans,Martiny, Lars,Fr?lund, Bente,Clausen, Rasmus P.
supporting information; experimental part, p. 6506 - 6510 (2010/11/18)
γ-Hydroxybutyric acid (GHB) is a psychotropic compound endogenous to the brain. Despite its potential physiological significance, the complete molecular mechanisms of action remain unexplained. To facilitate the isolation and identification of the high-affinity GHB binding site, we herein report the design and synthesis of the first 125I-labeled radioligands in the field, one of which contains a photoaffinity label which enables it to bind irreversibly to the high-affinity GHB binding sites.
