1245794-14-2

Basic information

• Product Name: (1-(((4-chloro-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropyl)carbamic acid benzyl ester
• Synonyms: (1-(((4-chloro-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropyl)carbamic acid benzyl ester
• CAS NO: 1245794-14-2
• Molecular Weight: 412.873
• Mol File: 1245794-14-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1-(((4-chloro-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropyl)carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1-(((4-chloro-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropyl)carbamic acid benzyl ester(1245794-14-2)
• EPA Substance Registry System: (1-(((4-chloro-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropyl)carbamic acid benzyl ester(1245794-14-2)

Safety Data

• Hazardous Substances Data: 1245794-14-2(Hazardous Substances Data)

Upstream product

• 205448-31-3 4-chloro-6-methoxy-7-hydroxyquinoline 
• 103500-22-7 1-(Benzyloxycarbonylamino)cyclopropanemethanol 
• 1245794-11-9 (1-(((4-hydroxy-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropyl)carbamate benzyl ester 
• 286371-49-1 7-(benzyloxy)-4-chloro-6-methoxyquinoline 
• 1058137-81-7 1-(benzyloxycarbonylamino)cyclopropylmethyl methanesulfonate 

Downstream Products

• 1058137-21-5 benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)methyl)cyclo-propylcarbamate 

Relevant articles and documents

Method for synthesizing N-protected quinoline-7-yl-oxymethyl cyclopropylamine derivative and synthetic intermediate

The invention relates to a method for synthesizing an N-protected quinoline-7-yl-oxymethyl cyclopropylamine derivative and a synthetic intermediate, in particular to a preparation method for synthesizing an N-protected (1-(((4-chloro-6-methoxyquinoline-7-

A PROCESS FOR THE PREPARATION OF 6-(7-((1-AMINOCYCLOPROPYL)METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND SYNTHETIC INTERMEDIATES THEREOF

A process for the preparation in high yields and purity of the compound 6-(7-((l-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl- 1 -naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.