1058137-21-5

Basic information

• Product Name: benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)methyl)cyclo-propylcarbamate
• Synonyms: benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)methyl)cyclo-propylcarbamate
• CAS NO: 1058137-21-5
• Molecular Weight: 577.637
• Mol File: 1058137-21-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)methyl)cyclo-propylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)methyl)cyclo-propylcarbamate(1058137-21-5)
• EPA Substance Registry System: benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)methyl)cyclo-propylcarbamate(1058137-21-5)

Safety Data

• Hazardous Substances Data: 1058137-21-5(Hazardous Substances Data)

Upstream product

• 847802-91-9 6-hydroxy-N-methyl-1-naphthalenecarboxamide 
• 1245794-14-2 (1-(((4-chloro-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropyl)carbamic acid benzyl ester 
• 1058137-81-7 1-(benzyloxycarbonylamino)cyclopropylmethyl methanesulfonate 
• 1058137-80-6 6-(7-hydroxy-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide 
• 1058137-76-0 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)methyl)cyclopropanecarboxylic acid 
• 100-51-6 benzyl alcohol 
• 543-27-1 isobutyl chloroformate 

Downstream Products

• 1058137-23-7 lucitanib 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF 6-(7-((1-AMINOCYCLOPROPYL)METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND SYNTHETIC INTERMEDIATES THEREOF

A process for the preparation in high yields and purity of the compound 6-(7-((l-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl- 1 -naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.