1245905-57-0

Basic information

• Product Name: (R)-5-(trifluoromethyl)-4,5-dihydro-3,5-diphenylisoxazole
• Synonyms: (R)-5-(trifluoromethyl)-4,5-dihydro-3,5-diphenylisoxazole
• CAS NO: 1245905-57-0
• Molecular Weight: 291.273
• Mol File: 1245905-57-0.mol

Chemical Properties

• CAS DataBase Reference: (R)-5-(trifluoromethyl)-4,5-dihydro-3,5-diphenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-(trifluoromethyl)-4,5-dihydro-3,5-diphenylisoxazole(1245905-57-0)
• EPA Substance Registry System: (R)-5-(trifluoromethyl)-4,5-dihydro-3,5-diphenylisoxazole(1245905-57-0)

Safety Data

• Hazardous Substances Data: 1245905-57-0(Hazardous Substances Data)

Upstream product

• 146801-38-9 (E)-4,4,4-trifluoro-1,3-diphenyl-2-buten-1-one 
• 1373154-77-8 (R)-4,4,4-trifluoro-3-hydroxy-1,3-diphenylbutan-1-one 
• 146801-19-6 4,4,4-trifluoro-3-hydroxy-1,3-diphenyl-1-butanone 

Relevant articles and documents

Enantioselective synthesis of 5-trifluoromethyl-2-isoxazolines and their N-oxides by [hydroxy(tosyloxy)iodo]benzene-mediated oxidative N-O coupling

Biologically attractive trifluoromethyl-2-isoxazoline N-oxides were synthesized in good yields for the first time by the [hydroxy(tosyloxy)iodo] benzene-mediated oxidative N-O coupling of β-trifluoromethyl β-hydroxy ketoximes generated from trifluoromethyl β-keto alcohols. The present method allows the synthesis of previously unknown 5-trifluoromethyl-2- isoxazoline N-oxides and also provides an alternative for the enantioselective synthesis of antiparasitic 5-trifluoromethyl-2-isoxazolines by sequential reduction. Biologically attractive trifluoromethyl-2-isoxazoline N-oxides were synthesized in good yields by the [hydroxy(tosyloxy)iodo]benzene-mediated oxidative N-O coupling of β-trifluoromethyl β-hydroxy ketoximes. This is the first synthesis of 5-trifluoromethyl-2-isoxazoline N-oxides, and this method provides an alternative for the enantioselective synthesis of antiparasitic 5-trifluoromethyl-2-isoxazolines. Copyright

Enantioselective synthesis of trifluoromethyl-substituted 2-isoxazolines: Asymmetric hydroxylamine/enone cascade reaction

(Figure Presented) Cuts both ways: The title reaction consists of an addition/cyclization/dehydration sequence and affords the biologically important chiral 3,5-diaryl-5-(trifluoromethyl)-2-isoxazolines 1 in excellent yields with high ee values. The flexi