1373154-77-8

Basic information

• Product Name: (R)-4,4,4-trifluoro-3-hydroxy-1,3-diphenylbutan-1-one
• Synonyms: (R)-4,4,4-trifluoro-3-hydroxy-1,3-diphenylbutan-1-one
• CAS NO: 1373154-77-8
• Molecular Weight: 294.273
• Mol File: 1373154-77-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (R)-4,4,4-trifluoro-3-hydroxy-1,3-diphenylbutan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4,4,4-trifluoro-3-hydroxy-1,3-diphenylbutan-1-one(1373154-77-8)
• EPA Substance Registry System: (R)-4,4,4-trifluoro-3-hydroxy-1,3-diphenylbutan-1-one(1373154-77-8)

Safety Data

• Hazardous Substances Data: 1373154-77-8(Hazardous Substances Data)

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 98-86-2 acetophenone 
• 212378-97-7 (R(S))-N-(1-phenylethylidene)-tert-butanesulfinamide 
• 614-20-0 3-oxo-3-phenylpropionic acid 

Downstream Products

• 1245905-57-0 (R)-5-(trifluoromethyl)-4,5-dihydro-3,5-diphenylisoxazole 

Relevant articles and documents

Biomimetic catalytic enantioselective decarboxylative aldol reaction of β-ketoacids with trifluoromethyl ketones

We disclose an organocatalyzed enantioselective decarboxylative ketone aldol reaction of β-ketoacids with trifluoromethyl ketones in the presence of biscinchona alkaloid (DHQD)2AQN, affording chiral tertiary alcohols in up to 98% yield and 90% ee. The Royal Society of Chemistry 2012.

Catalytic Enantioselective Direct Aldol Addition of Aryl Ketones to α-Fluorinated Ketones

The catalytic enantioselective synthesis of α-fluorinated chiral tertiary alcohols from (hetero)aryl methyl ketones is described. The use of a bifunctional iminophosphorane (BIMP) superbase was found to facilitate direct aldol addition by providing the strong Br?nsted basicity required for rapid aryl enolate formation. The new synthetic protocol is easy to perform and tolerates a broad range of functionalities and heterocycles with high enantioselectivity (up to >99:1 e.r.). Multi-gram scalability has been demonstrated along with catalyst recovery and recycling. 1H NMR studies identified a 1400-fold rate enhancement under BIMP catalysis, compared to the prior state-of-the-art catalytic system. The utility of the aldol products has been highlighted with the synthesis of various enantioenriched building blocks and heterocycles, including 1,3-aminoalcohol, 1,3-diol, oxetane, and isoxazoline derivatives.

PRODUCTION METHOD OF OPTICALLY ACTIVE β-HYDROXYKETONE COMPOUND

PROBLEM TO BE SOLVED: To provide a new method for producing an optically active β-hydroxyketone compound. SOLUTION: A production method of an optically active compound represented by formula (4) is provided, which comprises allowing a compound represented