1245905-85-4

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 17614-89-0 (2-(4-methoxyphenyl)-2-oxoethyl)triphenylphosphonium bromide 
• 53094-78-3 [2-(4-Methoxy-phenyl)-2-oxo-ethyl]-triphenyl-phosphonium; chloride 
• 1777-55-5 (4-methoxyphenacylidene)triphenyl phosphorane 

Downstream Products

• 1245905-69-4 (R)-5-(trifluoromethyl)-4,5-dihydro-3-(4-methoxyphenyl)-5-phenylisoxazole 
• 92-52-4 biphenyl 
• 1226965-56-5 4,4,4-trifluoro-1-(4-methoxyphenyl)-3-phenyl-1-butanone 
• 1380297-52-8 (R)-4-(4-methoxyphenyl)-4-oxo-2-phenyl-2-(trifluoromethyl)butanenitrile 

Relevant academic research and scientific papers

A Copper-Catalyzed Reductive Defluorination of β-Trifluoromethylated Enones via Oxidative Homocoupling of Grignard Reagents

An efficient copper-catalyzed reductive defluorination of β-trifluoromethylated enones via an oxidative homocoupling of Grignard reagents is reported. The reaction proceeded smoothly with a wide range of substrates, including the ones bearing aromatic heterocycles, such as furyl and thienyl ring systems in high yields (80-92%, except one example) under mild conditions. This provides a practical method for synthesis of gem-difluoroolefin ketones. It is also worth noting that this homocoupling process of Grignard reagents using β-trifluoromethylated enones as oxidizing reagents is effective for both the Csp2-Csp2 and Csp3-Csp3 bond formations, including for substrates whose β-hydride elimination of the corresponding transition metal alkyl complex is particularly facile, affording coupling products with high yields (83-95%), simultaneously.

Catalytic Enantioselective Conjugate Alkynylation of β-Aryl-β-trifluoromethyl Enones Constructing Propargylic All-Carbon Quaternary Stereogenic Centers

The enantioselective conjugate alkynylation of β-aryl-β-trifluoromethyl enones has been carried out using terminal alkynes and diethylzinc in the presence of 3,3′-bis(perfluorophenyl)BINOL as the chiral ligand to give the corresponding ketones bearing a t

Efficient and highly enantioselective construction of trifluoromethylated quaternary stereogenic centers via high-pressure mediated organocatalytic conjugate addition of nitromethane to β,β-disubstituted enones

A very effective high-pressure-induced acceleration of asymmetric organocatalytic conjugate addition of nitromethane to sterically congested β,β-disubstituted β-CF3 enones has been developed. A combination of pressure (8-10 kbar) and noncovalent catalysis with low-loading of chiral tertiary amine-thioureas (0.5-3 mol %) is shown to provide very efficient access to a wide range of γ-nitroketones containing trifluoromethylated all-carbon quaternary stereogenic centers in the β-position (80-97%, 92-98% ee).

Enantioselective synthesis of trifluoromethyl-substituted 2-isoxazolines: Asymmetric hydroxylamine/enone cascade reaction

(Figure Presented) Cuts both ways: The title reaction consists of an addition/cyclization/dehydration sequence and affords the biologically important chiral 3,5-diaryl-5-(trifluoromethyl)-2-isoxazolines 1 in excellent yields with high ee values. The flexi