1245908-00-2Relevant academic research and scientific papers
Asymmetric conjugate addition of α-keto esters to nitroolefins catalyzed by chiral CuII hydroxo complexes
Nakamura, Ayako,Lectard, Sylvain,Shimizu, Ryo,Hamashima, Yoshitaka,Sodeoka, Mikiko
experimental part, p. 1682 - 1687 (2010/10/19)
As a part of our research project on hard anion-late transition metal complexes as mild acid-base catalysts, we describe herein that CuII hydroxo complexes having chiral N-substituted-diaminocyclohexanes are mild and selective catalysts, which are applicable to the catalytic asymmetric conjugate addition of α-keto esters to nitroolefins. The reaction proceeded diastereoselectively without the detectable formation of self-aldol products, affording the corresponding coupling products with anti-stereochemistry in an enantioselective manner.
