1245927-54-1Relevant articles and documents
Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties
Rheault, Tara R.,Donaldson, Kelly H.,Badiang-Alberti, Jennifer G.,Davis-Ward, Ronda G.,Andrews, C. Webb,Bambal, Ramesh,Jackson, Jeffrey R.,Cheung, Mui
scheme or table, p. 4587 - 4592 (2010/10/02)
Potent inhibitors of PLK1 with acceptable solubility, mouse iv clearance, and reduced CYP450 inhibition were identified. Drug-like properties were improved using a heteroaryl ring as a functional handle for manipulation of inhibitors' physiochemical and DMPK properties.
