1246022-17-2Relevant academic research and scientific papers
Total synthesis of rhazinilam: Axial to point chirality transfer in an enantiospecific Pd-catalyzed transannular cyclization
Gu, Zhenhua,Zakarian, Armen
supporting information; experimental part, p. 4224 - 4227 (2010/11/17)
Figure Presented. A total synthesis of rhazinilam based on a transannular cyclization strategy is described. Using a Heck reaction, the axial chirality of a halogenated 13-membered lactam can be exploited to create the quaternary chiral stereogenic center in the target molecule with high enantiospecificity.
