1246022-19-4

Upstream product

• 1246022-17-2 2-(2-bromo-1H-pyrrol-3-yl)aniline 
• 1246022-15-0 (E)-tert-butyl 4-ethylidene-7-iodoheptanoate 

Downstream Products

• 1246022-20-7 (Z)-tert-butyl 7-(3-(2-aminophenyl)-2-iodo-1H-pyrrol-1-yl)-4-ethyleneheptanoate 

Relevant academic research and scientific papers

Total synthesis of rhazinilam: Axial to point chirality transfer in an enantiospecific Pd-catalyzed transannular cyclization

Figure Presented. A total synthesis of rhazinilam based on a transannular cyclization strategy is described. Using a Heck reaction, the axial chirality of a halogenated 13-membered lactam can be exploited to create the quaternary chiral stereogenic center in the target molecule with high enantiospecificity.