124604-00-8

Upstream product

• 124-41-4 sodium methylate 
• 83-13-6 diethyl 2-phenylmalonate 
• 92607-06-2 hydroxyphenylmalonic acid dimethyl ester 
• 74-88-4 methyl iodide 
• 5018-30-4 dimethyl methoxymalonate 

Relevant academic research and scientific papers

Synthesis of 2-Substituted 2-Arylmalonates via Tricarbonylchromium Complexes

Tricarbonylchromium complexes 1 react with monosubstituted malonic acid esters 2 in DMSO at room temperature in the presence of KOtBu to give the complexes 3. After oxidative demetalation, the appropriate aryl derivatives 4 are obtained in moderate to good overall yields. Diastereoselective arylations of chirally modified malonates such as 5a-c were studied. The stereoselectivity was highest for the products 6c/6c′ (80:20) with (-)-8-phenylmenthol as alcohol component in the malonate 5.

Electrochemical Hydroxylation, Methoxylation, and Hydroxymethylation of Active Methine Compounds

Hydroxylation, methoxylation, or hydroxymethylation at the active methine group of phenylmalonate, benzylmalonate and diphenylacetate were achieved by anodic oxidation.