1246089-97-3

Basic information

• Product Name: pyrotinib
• CAS NO: 1246089-97-3
• Molecular Weight: 583.09
• Mol File: 1246089-97-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: pyrotinib(CAS DataBase Reference)
• NIST Chemistry Reference: pyrotinib(1246089-97-3)
• EPA Substance Registry System: pyrotinib(1246089-97-3)

Safety Data

• Hazardous Substances Data: 1246089-97-3(Hazardous Substances Data)

Upstream product

• 848139-78-6 6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile 
• 1269662-79-4 diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate 
• 852324-29-9 (S)-N-methylpyrrolidine-2-carboxaldehyde 
• 852324-28-8 (2R)-1-methylpyrrolidine-2-formaldehyde 
• 121-88-0 5-Nitro-2-aminophenol 
• 933-94-8 N-Methyl-proline Methyl Ester 
• 43041-12-9 methyl pyrrolidine-2-carboxylate 
• 609-36-9 rac-Pro-OH 
• 13493-88-4 1-methylpyrrolidine-2-carboxaldehyde 
• 3554-65-2 1-methyl-2-pyrrolidine-methanol 
• 3554-65-2 (R)-N-methylpyrrolidine-2-methanol 

Relevant articles and documents

Preparation process of pyrotinib

The invention discloses a preparation process of pyrotinib, and belongs to the technical field of chemical synthesis of medicines. According to the method, (2E)-N-(4-amino-3-cyano-7-ethoxyquinolin-6-yl)-3-[(2R)-1-methylpyrrolidin-2-yl]acrylamide as shown in a formula I and 2-[(2-chloro-4-methylthiophenoxy)methyl]pyridine as shown in a formula II undergo a substitution reaction in a solvent under the action of a base catalyst to obtain pyrotinib. The preparation method has the characteristics of easily available raw materials, simple process, economy, environmental protection and the like, is beneficial to quality control and improvement of final product bulk drugs, and can meet the requirements of industrial production.

Preparation Method for Tyrosine Kinase Inhibitor and Intermediate Thereof

Provided is a preparation method for a tyrosine kinase inhibitor and an intermediate thereof. Specifically, a preparation method for a cyanoquinoline compound is provided. The method has a high yield, good product purity, and mild reaction conditions.

METHOD FOR PREPARING TYROSINE KINASE INHIBITOR AND DERIVATIVE THEREOF

The present invention relates to a method for preparing a tyrosine kinase inhibitor and a derivative thereof. The present method has a short synthesis route, low costs, easy operation, and is suitable for large-scale production.