124614-52-4Relevant academic research and scientific papers
Polyfluoroaralkyl amines. Further studies on the reactivity of 4,5,6,7-tetrafluoroindole
Filler, Robert,Woods, Sarah M.,White, William L.
, p. 1837 - 1841 (2007/10/02)
4,5,6,7-tetrafluoroindole 1 undergoes electrophilic formylation and aminoalkylation at C-3 to give compounds that can be readily converted to a variety of products, including the skatole, tryptamine, and tryptophan. 1 reacts with ethyl diazoacetate to yield 4,5,6,7-tetrafluoroethyl-3-indole acetate.The Grignard reagent of 1 offers a direct route to the versatile substituted acetonitrile 10 via C-3 alkylation with chloroacetonitrile.Key words: tetrafluoroindole, tetrafluorotryptamine, tetrafluoroindolyl magnesium bromide, tetrafluorotryptophan.
