1246226-70-9Relevant academic research and scientific papers
Palladium-catalyzed direct arylation using free NH2 substituted thiophene derivatives with inhibition of amination type reaction
Derridj, Fazia,Si Larbi, Karima,Roger, Julien,Djebbar, Safia,Doucet, Henri
experimental part, p. 7463 - 7471 (2012/09/10)
The palladium-catalyzed direct arylation at C2 or C5 of free NH2 substituted thiophene derivatives was found to proceed in moderate to high yields using a variety of aryl halides. The choice of potassium acetate as the base was found to be crucial to inhibit the amination reaction and to promote the direct arylation.
Palladium-catalyzed direct arylation of free NH2-substituted thiophene derivatives
Derridj, Fazia,Roger, Julien,Djebbar, Safia,Doucet, Henri
supporting information; experimental part, p. 4320 - 4323 (2010/11/18)
Figure Presented. The palladium-catalyzed direct 2- or 5-arylation of some free NH2-substituted thiophene derivatives was found to proceed in high yields using a variety of aryl bromides. In the course of these reactions, no coupling of the aryl bromide with the thiophene NH2 substituent was detected. The presence of an ester substituent on C2 of thiophene was found to be useful to block this highly reactive carbon.
