124623-09-2

Basic information

• Product Name: 2-amino-4-fluoropropiophenone
• Synonyms: 2-amino-4-fluoropropiophenone
• CAS NO: 124623-09-2
• Molecular Weight: 167.183
• Mol File: 124623-09-2.mol

Chemical Properties

• CAS DataBase Reference: 2-amino-4-fluoropropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-fluoropropiophenone(124623-09-2)
• EPA Substance Registry System: 2-amino-4-fluoropropiophenone(124623-09-2)

Safety Data

• Hazardous Substances Data: 124623-09-2(Hazardous Substances Data)

Upstream product

• 372-19-0 meta-fluoroaniline 
• 107-12-0 propiononitrile 

Relevant articles and documents

Synthesis and antitumor activity of 20(S)-camptothecin derivatives. A-ring-substituted 7-ethylcamptothecins and their E-ring-modified water-soluble derivatives

Twenty-six novel A-ring-modified 7-ethylcamptothecins (6) were synthesized by Friedlander's condensation of the chiral tricyclic ketone (5) with aminopropiophenones (4). The compounds substituted with fluorine at the 11 position showed strong cytotoxicity

Camptothecin derivatives

New campotothecin derivatives and a process for preparing same are disclosed, which are represented by the general formula: STR1 wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom or an amino, hydroxyl, lower acylamino or lower alkoxy group, R3 represents a hydrogen or halogen atom or a lower alkyl, hydroxyl, lower alkoxy, nitro, amino, cyano or di(lower alkyl)amino group, R4 represents a hydrogen or halogen atom or a lower alkyl, hydroxyl, lower alkoxy, lower alkylthio, amino, cyano or di(lower alkyl)amino group, and R5 represents a hydrogen or halogen atom or a hydroxyl or lower alkoxy group, with the proviso that all of the R2, R3, R4 and R5 substituents should not be a hydrogen atom and also that if any one of the R2, R3, R4 and R5 is a hydroxyl or lower alkoxy group, all of the other three substituents should not be a hydrogen atom.