1246277-51-9Relevant academic research and scientific papers
Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1 H -pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase
Talamas, Francisco X.,Abbot, Sarah C.,Anand, Shalini,Brameld, Ken A.,Carter, David S.,Chen, Jun,Davis, Dana,De Vicente, Javier,Fung, Amy D.,Gong, Leyi,Harris, Seth F.,Inbar, Petra,Labadie, Sharada S.,Lee, Eun K.,Lemoine, Remy,Le Pogam, Sophie,Leveque, Vincent,Li, Jim,McIntosh, Joel,Nájera, Isabel,Park, Jaehyeon,Railkar, Aruna,Rajyaguru, Sonal,Sangi, Michael,Schoenfeld, Ryan C.,Staben, Leanna R.,Tan, Yunchou,Taygerly, Joshua P.,Villase?or, Armando G.,Weller, Paul E.
, p. 1914 - 1931 (2014/04/03)
In the past few years, there have been many advances in the efforts to cure patients with hepatitis C virus (HCV). The ultimate goal of these efforts is to develop a combination therapy consisting of only direct-antiviral agents (DAAs). In this paper, we
HETEROCYCLIC ANTIVIRAL COMPOUNDS
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, (2012/03/09)
Compounds having the formula (I) wherein R1, R2, R3 and X are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV
