1246303-67-2Relevant academic research and scientific papers
BICYCLIC OXAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
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Paragraph 00503, (2013/09/12)
In one aspect, the invention relates to substituted bicyclic oxazole lactam analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Orthogonally protected thiazole and isoxazole diamino acids: An efficient synthetic route
Butler, Jeffrey D.,Coffman, Keith C.,Ziebart, Kristin T.,Toney, Michael D.,Kurth, Mark J.
supporting information; experimental part, p. 9002 - 9005 (2010/12/19)
An efficient strategy has been developed for the synthesis of heteroaromatic amino acids (HAAs). These methods generate mono-or orthogonally protected diamino acids from bamino acids (see scheme). Their synthetic reliability and biological potential was d
