1246303-75-2Relevant academic research and scientific papers
Isoxazolodihydropyridinones: 1,3-dipolar cycloaddition of nitrile oxides onto 2,4-dioxopiperidines
Coffman, Keith C.,Hartley, Timothy P.,Dallas, Jerry L.,Kurth, Mark J.
, p. 280 - 284 (2012/05/19)
Practical and efficient methods have been developed for the diversity-oriented synthesis of isoxazolodihydropyridinones via the 1,3-dipolar cycloaddition of nitrile oxides onto 2,4-dioxopiperidines. A select few of these isoxazolodihydropyridinones were further elaborated with triazoles by copper-catalyzed azide-alkyne cycloaddition reactions. A total of 70 compounds and intermediates were synthesized and analyzed for drug likeness. Sixty-four of these novel compounds were submitted to the NIH Molecular Libraries Small Molecule Repository for high-throughput biological screening.
Orthogonally protected thiazole and isoxazole diamino acids: An efficient synthetic route
Butler, Jeffrey D.,Coffman, Keith C.,Ziebart, Kristin T.,Toney, Michael D.,Kurth, Mark J.
supporting information; experimental part, p. 9002 - 9005 (2010/12/19)
An efficient strategy has been developed for the synthesis of heteroaromatic amino acids (HAAs). These methods generate mono-or orthogonally protected diamino acids from bamino acids (see scheme). Their synthetic reliability and biological potential was d
