1246312-06-0Relevant articles and documents
Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: Discovery of a novel TSPO PET ligand for cancer imaging
Tang, Dewei,McKinley, Eliot T.,Hight, Matthew R.,Uddin, Md. Imam,Harp, Joel M.,Fu, Allie,Nickels, Michael L.,Buck, Jason R.,Manning, H. Charles
, p. 3429 - 3433 (2013/06/05)
Focused library synthesis and structure-activity relationship development of 5,6,7-substituted pyrazolopyrimidines led to the discovery of 2-(5,7-diethyl-2-(4-(2-fluoroethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N, N-diethylacetamide (6b), a novel transl
Microwave-assisted organic synthesis of a high-affinity pyrazolo-pyrimidinyl TSPO ligand
Tang, Dewei,Buck, Jason R.,Hight, Matthew R.,Manning, H. Charles
supporting information; experimental part, p. 4595 - 4598 (2010/09/18)
We herein report a dramatically improved total synthesis of the high-affinity translocator protein (TSPO) ligand DPA-714, featuring microwave-assisted organic synthesis (MAOS). Compared with previously described approaches, our novel MAOS method dramatica