1246366-15-3Relevant academic research and scientific papers
Palladium-catalyzed intramolecular aminoacetoxylation of unactivated alkenes with hydrogen peroxide as oxidant
Zhu, Haitao,Chen, Pinhong,Liu, Guosheng
, p. 1485 - 1488 (2015)
A palladium-catalyzed intramolecular aminoacetoxylation of unactivated alkenes was developed in which H2O2 was used as the sole oxidant. A variety of 3-acetoxylated piperidines were obtained in good yields with good to excellent regio- and diastereoselectivities. Mechanistic study revealed that the addition of di(2-pyridyl) ketone (dpk) ligand was crucial to promote the oxidative cleavage of the C-Pd(II) bond by H2O2 to give the C-OAc bond.
Copper-catalyzed olefin aminoacetoxylation
Mancheno, Danny E.,Thornton, Aaron R.,Stoll, Armin H.,Kong, Aidi,Blakey, Simon B.
supporting information; experimental part, p. 4110 - 4113 (2010/11/04)
A new catalyst system for intramolecular olefin aminoacetoxylation is described. In contrast to previously reported palladium- and copper-catalyzed systems, the conditions outlined in this communication favor piperdine formation with terminal olefin subst
