1246401-53-5

Upstream product

• 1246401-81-9 N¹,N³-bis((R)-2-hydroxy-1-phenylethyl)-2,2-dipentylmalonamide 
• 110-53-2 1-Bromopentane 
• 4372-38-7 2,2-dipentylmalonic acid 
• 220776-75-0 diethyl 2,2-dipentylmalonate 

Relevant academic research and scientific papers

Copper(II)-catalyzed enantioselective intramolecular cyclization of N-alkenylureas

The first Cu(II)-catalyzed highly enantioselective intramolecular cyclization of N-alkenylureas was developed for the concise assembly of chiral vicinal diamino bicyclic heterocycles. Facile removal of carbonyl group of the carbamido moiety allowed for ready access to enantioenriched cyclic vicinal diamines.

A two-step mimic for direct, asymmetric bromonium- and chloronium-induced polyene cyclizations

Although direct, asymmetric, halonium-induced cyclizations have proven difficult to achieve in the absence of enzymes, this report provides a two-step alternative based on reacting polyenes with chiral mercury(II) complexes to afford a number of polycyclic organomercurials that can be subsequently converted, with retention, into their corresponding chlorine, bromine, and iodine derivatives in good yield and enantioselectivity. A five-step asymmetric total synthesis of the natural product 4-isocymobarbatol is also described.