1246401-79-5Relevant articles and documents
A two-step mimic for direct, asymmetric bromonium- and chloronium-induced polyene cyclizations
Snyder, Scott A.,Treitler, Daniel S.,Schall, Andreas
, p. 4796 - 4804 (2010)
Although direct, asymmetric, halonium-induced cyclizations have proven difficult to achieve in the absence of enzymes, this report provides a two-step alternative based on reacting polyenes with chiral mercury(II) complexes to afford a number of polycyclic organomercurials that can be subsequently converted, with retention, into their corresponding chlorine, bromine, and iodine derivatives in good yield and enantioselectivity. A five-step asymmetric total synthesis of the natural product 4-isocymobarbatol is also described.