93997-99-0Relevant articles and documents
Diastereoselective Synthesis of Highly Substituted Tetrahydrofurans by Pd-Catalyzed Tandem Oxidative Cyclization-Redox Relay Reactions Controlled by Intramolecular Hydrogen Bonding
Brooks, Joshua L.,Xu, Liping,Wiest, Olaf,Tan, Derek S.
, p. 57 - 75 (2017/04/26)
Palladium-catalyzed oxidative cyclization of alkenols provides a convenient entry into cyclic ethers but typically proceeds with little or no diastereoselectivity for cyclization of trisubstituted olefins to form tetrahydrofurans due to the similar energi
A two-step mimic for direct, asymmetric bromonium- and chloronium-induced polyene cyclizations
Snyder, Scott A.,Treitler, Daniel S.,Schall, Andreas
experimental part, p. 4796 - 4804 (2010/08/07)
Although direct, asymmetric, halonium-induced cyclizations have proven difficult to achieve in the absence of enzymes, this report provides a two-step alternative based on reacting polyenes with chiral mercury(II) complexes to afford a number of polycyclic organomercurials that can be subsequently converted, with retention, into their corresponding chlorine, bromine, and iodine derivatives in good yield and enantioselectivity. A five-step asymmetric total synthesis of the natural product 4-isocymobarbatol is also described.
