1246437-57-9Relevant academic research and scientific papers
Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold
He, Guijia,Dou, Dengfeng,Wei, Liuqing,Alliston, Kevin R.,Groutas, William C.
experimental part, p. 4280 - 4287 (2010/10/02)
A series of compounds based on the N-amino-4-imidazolidinone scaffold was synthesized and screened against human neutrophil elastase (HNE). These studies lead to the identification of a selective, low micromolar reversible competitive inhibitor of HNE. A series of derivatives based on the N-amino-4- imidazolidinone scaffold (I) was synthesized and shown to inhibit human neutrophil elastase.
