1246465-12-2Relevant academic research and scientific papers
Zinc-mediated asymmetric additions of dialkylphosphine oxides to α,β-unsaturated ketones and N -sulfinylimines
Zhao, Depeng,Mao, Lijuan,Yang, Dongxu,Wang, Rui
supporting information; experimental part, p. 6756 - 6763 (2010/11/24)
A catalyst was synthesized on the basis of Trosts dinuclear catalyst characterized by working well without pyridine in the present phospha-Michael reaction. Nevertheless, the presence of pyridine is still advantageous in the present system. The substrate scope was successfully extended to enones employing diallyl phosphine oxide as a nucleophile. Excellent yields and enantioselectivities (up to >99% ee) were achieved for a wide scope of enones employing the catalyst under mild conditions. The detailed reaction mechanism is also discussed herein. Finally, the unprecedented asymmetric additions of dialkylphosphine oxides to N-sulfinylimines were achieved by using Et 2Zn as a base.
