124647-48-9Relevant academic research and scientific papers
SYNTHESE DE PYRROLES ET D'OXAZOLES PAR PYROLYSE DE N-(HYDROXY-2' ETHYL) AMINO-3 PROPENOATE
Pale-Grosdemange, Catherine,Chuche, Josselin
, p. 3397 - 3414 (1989)
The gas phas pyrolysis of various N-(2'-hydroxyethyl)-3-amino propenoates 1-6 and N-(2'-hydroxy-2'-phenyl ethyl)-3-amino propanoate 7-9 at 390 deg C-420 deg C leads respectively to formylpyrroles 11-16 and benzoylpyrroles 17-19 and, in some cases, to substituted oxazoles 36-39.The results are best explained by the intermediate formation of a dicarbonyl derivative followed either by an intramolecular thermal crotonisation or a six ? electrocyclization of an azomethine ylide.
Synthesis of N-modified 4-aminopyridine-3-carboxylates by ring transformation
Nishiwaki, Nagatoshi,Nishimoto, Toyosato,Tamura, Mina,Ariga, Masahiro
, p. 1437 - 1439 (2006)
3-Methyl-5-nitropyrimidin-4(3H)-one reacted with enaminones to cause the ring transformation leading to functionalized 4-aminopyridines. Various kinds of amino groups can be introduced at the 4-position by modifying the enaminones. The modification of its vicinal positions was also possible. In addition, a bicyclic pyridine could be synthesized by making use of the vicinal functionality of a 4-aminopyridine-3-carboxylic acid. Georg Thieme Verlag Stuttgart.
