1246536-35-5Relevant academic research and scientific papers
COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR
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Paragraph 0164; 0169-0170, (2020/12/22)
The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical compsosition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.
Synthesis and anticonvulsant activity of new 6-methyl-1-substituted-4,6- diazaspiro[2.4]heptane-5,7-diones
He, Xianran,Qiu, Guanpeng,Yang, Jin,Xiao, Yuling,Wu, Zhongyuan,Qiu, Guofu,Hu, Xianming
experimental part, p. 3818 - 3830 (2010/09/10)
In the present study on the development of new anticonvulsants, twenty new 6-methyl-1-substituted-4,6-diazaspiro[2.4]heptane-5,7-diones were synthesized and tested for anticonvulsant activity using the maximal electroshock (MES) and subcutaneous pentylene
