124659-35-4Relevant academic research and scientific papers
Tri-aza macrocycles and metal complexes thereof
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, (2008/06/13)
Tri-aza macrocycles of formula (I), wherein m and n, which may be the same or different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R1, R2 and R3, which may be the same or different, is each a hydrogen atom or an alkyl, alkoxyalkyl, --CO2 H, ---SO3 H, PO3 H2 or aryl group; L is a covalent bond or linker group; Z is a hydrogen atom or a reactive functional group, with the proviso that when L is a covalent bond Z is a reactive functional group; and metal complexes and/or salts thereof are described together with processes for their preparation and compositions containing them. The compounds are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and are particularly suitable for coupling to other molecules such as proteins for use in diagnosis and therapy. STR1
Towards Tumour Imaging with Indium-111 Labelled Macrocycle-Antibody Conjugates
Craig, Andrew S.,Helps, Ian M.,Jankowski, Karl J.,Parker, David,Beeley, Nigel R. A.,et al.
, p. 794 - 796 (2007/10/02)
C-Functionalised triazacyclododecane and triazacyclononane triacid macrocycles have been covalently attached to a monoclonal antibody and may be labelled with 111In to form kinetically inert radiolabelled complexes.
