1246635-34-6Relevant academic research and scientific papers
Glycosidase inhibition with fullerene iminosugar balls: A dramatic multivalent effect
Compain, Philippe,Decroocq, Camille,Iehl, Julien,Holler, Michel,Hazelard, Damien,Barragan, Teresa Mena,Mellet, Carmen Ortiz,Nierengarten, Jean-Francois
, p. 5753 - 5756 (2010)
(Figure Presented) Superball ! A dodecavalent iminosugar derivative with a fullerene core (see picture) shows a binding enhancement of up to three orders of magnitude over the corresponding monovalent ligand in glycosidase inhibition assays. This is the first evidence of a significant multivalent effect in glycosidase inhibition.
Synthesis of glycosylamines and glyconamides using molecular iodine
Fusaro, Maxime B.,Chagnault, Vincent,Postel, Denis
, p. 542 - 550 (2013/07/27)
We describe herein the synthesis of glyconamides and glycosylamines usingmolecular iodine on benzylated carbohydrates. During the improvement and the optimization of the direct oxidative amidation reaction,we also discovered the possibility to form glycosylamines with excellent yields and short reaction times in comparison with the previously reported procedures. Advantages of these methods are the operational simplicity, elimination of use of complicated reagents and procedures, and generality of the reactions. Our methodology is an excellent access to precursors of N-alkyliminosugars and imino-C-glycosides.
Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain
Ardes-Guisot, Nicolas,Alonzi, Dominic S.,Reinkensmeier, Gabriele,Butters, Terry D.,Norez, Caroline,Becq, Frederic,Shimada, Yousuke,Nakagawa, Shinpei,Kato, Atsushi,Bleriot, Yves,Sollogoub, Matthieu,Vauzeilles, Boris
, p. 5373 - 5388 (2011/08/22)
A series of neoglycoconjugates derived from deoxynojirimycin has been prepared by click connection with functionalised adamantanes. They have been assayed as glycosidase inhibitors, as inhibitors of the glycoenzymes relevant to the treatment of Gaucher disease, as well as correctors of the defective ion-transport protein involved in cystic fibrosis. We have demonstrated that it is possible to selectively either strongly inhibit ER-α-glucosidases and ceramide glucosyltransferase or restore the activity of CFTR in CF-KM4 cells by varying the length of the alkyl chain linking DNJ and adamantane.
