124665-32-3Relevant academic research and scientific papers
Rh(I)-catalyzed [5 + 1] cycloaddition of vinylcyclopropanes and CO for the synthesis of α,β- and β,γ-cyclohexenones
Jiang, Guo-Jie,Fu, Xu-Fei,Li, Qian,Yu, Zhi-Xiang
supporting information; experimental part, p. 692 - 695 (2012/03/26)
A cationic Rh(I)-catalyzed [5 + 1] cycloaddition of vinylcyclopropanes and CO has been developed, affording either β,γ-cyclohexenones as major products or α,β-cyclohexenones exclusively, under different reaction conditions.
Regiospecific and stereoselective syntheses of (±)-reserpine and (-)-reserpine
Stork, Gilbert,Tang, Peng Cho,Casey, Michael,Goodman, Burton,Toyota, Masahiro
, p. 16255 - 16262 (2007/10/03)
Full details of three approaches to an entirely regio- and Stereoselective synthesis of the well-known target reserpine are described, culminating in a total synthesis which efficiently meets these requirements.
Tremorgenic Indole Alkaloids. 9. Asymmetric Construction of an Advanced F-G-H-Ring Lactone Precursor for the Synthesis of Penitrem D
Smith, Amos B.,Nolen, Ernest G.,Shirai, Ryuichi,Blase, Frances R.,Ohta, Mitsuaki,et al.
, p. 7837 - 7848 (2007/10/03)
Lactone (+)-12 is envisioned as the precursor to the F-G-H rings of penitrem D (4) in our ongoing synthetic venture.The efficient, stereocontrolled introduction of the vicinal quaternary methyl groups present the major challenge in the construction of this subunit.Our first route to (+/-)-12 was marked by low overall yield (2percent) and the instability of several key intermediates; these deficiencies were rectified in a second-generation approach that produced optically active material (18 steps from 19a, 2.1percent overall).The successful strategies exploited enolate generation via either conjugate additions to α,β-enones or the Evans oxy-Cope rearrangement as key regiochemical control elements.
