16807-60-6

Basic information

• Product Name: 3-METHOXY-2-CYCLOHEXEN-1-ONE
• Synonyms: 3-METHOXY-2-CYCLOHEXEN-1-ONE;3-methoxycyclohex-2-en-1-one;2-Cyclohexen-1-one, 3-methoxy-;3-METHOXY-2-CYCLOHEXEN-1-ONE 99+%;1-Methoxycyclohexene-3-one;Einecs 240-837-0;3-Methoxycyclohex-2-enone;3-METHOXY-2-CYCLOHEXEN-1-ONE FOR SYNTHES
• CAS NO: 16807-60-6
• Molecular Formula: C₇H₁₀O₂
• Molecular Weight: 126.15
• EINECS: 240-837-0
• Mol File: 16807-60-6.mol
• Article Data: 41

Chemical Properties

• Boiling Point: 233℃
• Flash Point: 104℃
• Appearance: /
• Density: 1.03
• Vapor Pressure: 0.0576mmHg at 25°C
• Refractive Index: 1.467
• Storage Temp.: Store below +30°C.
• CAS DataBase Reference: 3-METHOXY-2-CYCLOHEXEN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXY-2-CYCLOHEXEN-1-ONE(16807-60-6)
• EPA Substance Registry System: 3-METHOXY-2-CYCLOHEXEN-1-ONE(16807-60-6)

Safety Data

• Hazardous Substances Data: 16807-60-6(Hazardous Substances Data)

Usage

General Description

3-Methoxy-2-cyclohexen-1-one, also known as methoxycyclohexenone, is a chemical compound with the molecular formula C7H10O2. It is a colorless to pale yellow liquid with a sweet, floral odor. 3-METHOXY-2-CYCLOHEXEN-1-ONE is commonly used in the fragrance and flavor industries as a scent additive in products such as perfumes, soaps, and cosmetics. It is also used as an intermediate in the synthesis of other organic compounds. Additionally, 3-methoxy-2-cyclohexen-1-one has potential applications in the pharmaceutical and agrochemical industries due to its unique chemical properties. However, it is important to handle this compound with care as it can cause irritation to the eyes, skin, and respiratory system if not properly managed. Overall, 3-methoxy-2-cyclohexen-1-one is a versatile chemical with a range of industrial and commercial uses.

InChI:InChI=1/C7H10O2/c1-9-7-4-2-3-6(8)5-7/h5H,2-4H2,1H3

Upstream product

• 917-58-8 potassium ethoxide 
• 504-02-9 1,3-cylohexanedione 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 58697-12-4 iodure de methylammonio-2 cyclohexene-2 one 
• 58697-08-8 iodure de methyl piperidinio-2 cyclohexene-2 one 
• 15791-03-4 1,1,4,4-tetramethoxycyclohexa-2,5-diene 
• 74-88-4 methyl iodide 
• 149-73-5 trimethyl orthoformate 
• 112630-10-1 Dihydroresorcinol 
• 5682-75-7 3-chloro-2-cyclohexenone 
• 56671-82-0 3-Iodocyclohex-2-enone 
• 53293-00-8 hex-5-ynoic acid 
• 931-57-7 1-methoxy-cyclohex-1-ene 

Downstream Products

• 82207-07-6 2-(3-Oxo-cyclohex-1-enylmethyl)-furan-3-carboxylic acid 
• 108186-34-1 (1S,6R,7R)-7-Ethoxy-6-methoxy-bicyclo[4.2.0]octan-2-one 
• 108186-34-1 (1S,6R,7S)-7-Ethoxy-6-methoxy-bicyclo[4.2.0]octan-2-one 
• 108186-34-1 (1R,6R,7R)-7-Ethoxy-6-methoxy-bicyclo[4.2.0]octan-2-one 
• 108186-34-1 (1R,6R,7S)-7-Ethoxy-6-methoxy-bicyclo[4.2.0]octan-2-one 
• 132783-32-5 Chloro-acetic acid 4-methoxy-2-oxo-cyclohex-3-enyl ester 
• 91817-43-5 methyl (+/-)-4-methoxy-2-oxo-3-cyclohexene-1-carboxylate 
• 132783-31-4 Benzoic acid 4-methoxy-2-oxo-cyclohex-3-enyl ester 
• 61563-72-2 Methanesulfonic acid 3-(3-oxo-cyclohex-1-enyl)-propyl ester 
• 25308-67-2 spiro[2.5]octan-5-one 
• 58133-98-5 2-methyl-2,6,7,8-tetrahydro-chromen-5-one 
• 87887-08-9 3-(2-bromo-3-oxocyclohex-1-enyl)hexahydro-1-methylazepin-2-one 
• 87887-09-0 3-(2-bromo-3-oxocyclohex-1-enyl)-3-ethylhexahydro-1-methylazepin-2-one 
• 6301-49-1 3-butylcyclohexenone 

Relevant articles and documents

Nickel-catalyzed regio- and stereoselective homo 1,4-dialkenylation of conjugated dienes

2,3-Dimethyl-1,3-butadiene and cyclic dienes react with β-iodoenones (RI: 3-Iodo-2-cyclohexen-1-one, 5,5-dimethyl-3-iodo-2-cyclohexen-1-one and 3-iodo-2-cyclopenten-1-one) in the presence of Zn and catalytic amount of NiBr2 to afford the corresponding homo 1,4-addition products in good yields. For 2,3-dimethyl-1,3-butadiene, only the products RCH2C(CH3)=C(CH3)CH2R with Z geometry were observed. For cyclic dienes, the products observed are RCHCH=CHCHR(CH2)(n)CH2 in which the two alkenyl substituents R are cis to each other.

Rapid and Multigram Synthesis of Vinylogous Esters under Continuous Flow: An Access to Transetherification and Reverse Reaction of Vinylogous Esters

An environmentally benign approach for the synthesis of vinylogous esters from 1,3-diketone and its reverse reaction under continuous-flow has been developed with alcohols in the presence of inexpensive Amberlyst-15 as a catalyst. This methodology is highly selective and general for a range of cyclic 1,3-dicarbonyl compounds which gives a library of linear alkylated and arylated vinylogous esters in good to excellent yield under solvent and metal free condition. Furthermore, the long-time experiment in a continuous-flow up to 40 h afforded 8.0 g of the vinylogous ester with turnover number (TON) = 28.6 and turnover frequency (TOF) = 0.715 h-1 using Amberlyst-15 as a catalyst. Furthermore, a continuous-flow sequential transetherification of vinylogous esters with various alcohols has been achieved in high yield. Reversibly, this vinylogous ester was deprotected or hydrolyzed into ketone using environmentally benign water as a solvent and Amberlyst-15 as a catalyst under continuous-flow process.

Arene Trifunctionalization with Highly Fused Ring Systems through a Domino Aryne Nucleophilic and Diels–Alder Cascade

A convenient and efficient domino aryne process was developed under transition-metal-free conditions to generate a range of tetra- and pentacyclic ring systems. This transformation was realized via a 1,2-benzdiyne through a nucleophilic and Diels–Alder reaction cascade using styrene as the diene moiety. Three new chemical bonds, namely one C?N and two C?C bonds, and two benzofused rings could be constructed concomitantly, which was made possible by distinct chemoselective control at both the 1,2-aryne and 2,3-aryne stages. Moreover, in-depth studies were carried out on the domino aryne precursors and controlling the diastereoselectivity.