1246665-83-7Relevant academic research and scientific papers
Lactone pathway to statins utilizing the wittig reaction. the synthesis of rosuvastatin
Casar, Zdenko,Steinbuecher, Miha,Kosmrlj, Janez
, p. 6681 - 6684 (2010)
The first entry to statins via lactonized side chain is reported, exemplified by the synthesis of rosuvastatin. The key step is Wittig coupling of (2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-carbaldehyde and phosphonium salt of an appropriately functionalized pyrimidine heterocy'le. One-pot deprotection and hydrolysis of the resulting 4-O-TBS rosuvastatin lactone provided rosuvastatin in high yield.
