1444772-05-7

Basic information

• Product Name: N-(4-(4-fluorophenyl)-5-((Z)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
• Synonyms: N-(4-(4-fluorophenyl)-5-((Z)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
• CAS NO: 1444772-05-7
• Molecular Weight: 463.53
• Mol File: 1444772-05-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-(4-fluorophenyl)-5-((Z)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(4-fluorophenyl)-5-((Z)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide(1444772-05-7)
• EPA Substance Registry System: N-(4-(4-fluorophenyl)-5-((Z)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide(1444772-05-7)

Safety Data

• Hazardous Substances Data: 1444772-05-7(Hazardous Substances Data)

Upstream product

• 1246665-84-8 N-(5-((Z)-2-((2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide 

Relevant articles and documents

Conformational analysis of E/Z-isomeric pairs of rosuvastatin and its lactonized analogues

Most of the super-statins contain a CC double bond spacer between the heterocyclic and the chiral dihydroxycarboxylic moieties. The known drugs are E-geometric isomers, whereas very little is known about their Z-isomeric analogues. This study explains the unusual resonance line broadening observed in 1H NMR spectra of Z-isomeric rosuvastatin analogues at room temperature, which originates from dynamic exchange between different conformers. Conformational equilibria and intrinsic preferences of Z-isomeric rosuvastatin analogues provide valuable insight into conformational variability that is important for studying potential interactions within the binding site of the enzyme.